Search results for "Ciliary activity"

showing 2 items of 2 documents

The influence of Ca2+ antagonists on the ciliary activity of the guinea pig trachea.

1990

The ciliary activity of the guinea pig tracheal respiratory epithelium was measured using a photoelectric device. Fourteen animals were administered 75 mg diltiazem/kg body weight 2 days, 1 day and 4 h prior to the investigation. Thirteen animals served as controls. In the pretreated group, the mean ciliary stroke frequency (13.4 +/- 3.0 Hz) was significantly lower (P = 0.02) than in the control group (16.6 +/- 3.7 Hz). The application of aerosolized 0.3 mmol/l nifedipine solution on the tracheal preparations of the control animals also significantly reduced the stroke frequency (P = 0.02). The ciliary activity never dropped beyond a frequency of about 8 Hz. The most probable interpretation…

medicine.medical_specialtyNifedipineGuinea PigsGuinea pigDiltiazemNifedipineInternal medicineMedicineAnimalsDiltiazemCiliaRespiratory systemVoltage-dependent calcium channelbusiness.industryCiliary activityGeneral MedicineRinger's SolutionTracheaEndocrinologymedicine.anatomical_structureOtorhinolaryngologyMucociliary ClearanceAnesthesiaRespiratory epitheliumCalciumIsotonic SolutionsbusinessRespiratory tractmedicine.drugEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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Effect of sulfur dioxide on mucociliary activity and ciliary beat frequency in guinea pig trachea

1994

The effects of 30 min exposure to sulfur dioxide on mucociliary activity (MCA) and ciliary beat frequency (CBF) were studied in 31 guinea pig tracheas. MCA was measured by recording the light reflected from ciliated mucous membranes using an infrared bar code reader. CBF of single ciliated cells obtained by brushing was measured with phase-contrast microscopy. Each tracheal sample was exposed to SO2 at concentrations ranging from 2.5 to 12.5 ppm, or to air for control purposes. MCA and CBF were measured before and immediately after gas exposure. A reduction in mean MCA of 63% (P = 0.0007) and statistically insignificant changes in CBF (P > 0.05) were recorded at concentrations of 2.5 PPM SO…

Baseline valuesDose-Response Relationship DrugInhalationMucociliary clearanceCiliary activityGuinea PigsPublic Health Environmental and Occupational Healthcomplex mixturesTracheaAndrologyGuinea pigchemistry.chemical_compoundchemistryMucociliary ClearanceAnesthesiaToxicitycardiovascular systemAnimalsSulfur DioxideCiliary beatingSulfur dioxideCiliary Motility Disorderscirculatory and respiratory physiologyInternational Archives of Occupational and Environmental Health
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